Figure 1. The effect of leptin on the hypoxic ventilatory response in C57BL/6J mice.

A, experimental design of the hypoxic ventilatory response (HVR) experiment in C57BL/6J mice before and after subcutaneous leptin infusion via an osmotic pump (120 μg/day) before and after carotid sinus nerve denervation (CSND); B and C, oxyhaemoglobin saturation ($S_{\mathrm{p}{\mathrm{O}}_2}$) in C57BL/6J mice exposed to normoxia and hypoxia before and after CSND (n = 9, B) or sham surgery (n = 5, D); D and E, $S_{\mathrm{p}{\mathrm{O}}_2}$ in db/db mice exposed to normoxia and hypoxia at baseline and after carotid body area infection with Ad‐LacZ (n = 6, D) or Ad‐LepR^b (n = 9, E).