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. 2018 Oct 2;8(1):58–65. doi: 10.1002/sctm.18-0069

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© 2018 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A): Leydig stem cells function was validated by comparing the production of testosterone, follicle‐stimulating hormone, and luteinizing hormone in negative control (castrated), autograft, sham, and positive control (testopel) using enzyme‐linked immunosorbent assay. (B): To further confirm that it is the stem Leydig cells that undergo differentiation in the grafts, hormone levels were compared after 15 days and 1‐month autograft. (C): Immunostaining showing 3BHSD expressing cells in autografts from 15 days and 1‐month autograft. Significance of differences was calculated using t test; **, p < .01; *, p < .05, and ns (non‐significant) (p > .05). Abbreviations: BHSD, beta hydroxysteroid dehydrogenase; DAPI, 4′,6‐diamidino‐2‐phenylindole; FSH, follicle‐stimulating hormone; LH, luteinizing hormone.