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. Author manuscript; available in PMC: 2020 Jan 10.
Published in final edited form as: Int J Pharm. 2018 Nov 3;554:302–311. doi: 10.1016/j.ijpharm.2018.11.005

Table 3.

DoE statistical results

a1x1 a2x2 a3x3 a12x1x2 a23x2x3 a13x1x3 b R2 p
y1 3.04 −3.79 33.71 −3.44 0.89 9.12 66.95 0.84 0.126
y2 0.39 −5.96 36.09 0.03 −0.51 7.61 69.11 0.87 0.084
y3 254.58 −1963.66 3747.09 −52.92 −317.50 324.64 15178.3 0.84 0.129
y4 −0.01 0.22 −1.02 0.01 0.01 0.08 5.86 0.96 0.004