Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters of ARI, N6, or N6 tablet blend after a single oral dose of 20 mg/kg to rats. Each value represents the mean ± S.D. (n=6). * P < 0.05, compared to pure ARI; # P < 0.05, compared to N6
| Parameter | ARI | N6 | N6 tablet blend |
|---|---|---|---|
| Cmax (ng/mL) | 166.0 ± 34.7 | 320.0 ± 48.0* | 279.0 ± 10.0* |
| Tmax (h) | 2 | 2 | 2 |
| AUC0–12 (ng h/mL) | 832.0 ± 201.0 | 1302.0 ± 80.3* | 1329.0 ± 119.0* |
| t1/2 (h) | 5.26 ± 0.65 | 4.17 ± 0.39 | 8.32 ± 0.21*, # |
