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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Anat Rec (Hoboken). 2018 Oct 5;302(1):136–145. doi: 10.1002/ar.23909

Figure 6. Total Anomalous Pulmonary Venous Return (TAPVR) in the col3.6-cre;Ift88∆/fl mouse.

Figure 6.

Serial H/E stained section of a control heart (A) and four col3.6-cre;Ift88∆/fl mouse embryos (B-E) at ED14.5. Panel A shows the normal anatomy of the right and left pulmonary veins entering the left atrium through the common pulmonary orifice. In the mutant in B the pulmonary veins enter to the right of the rudimentary primary atrial septum in the posterior right atrial wall. In C a single pulmonary vein connects to the heart in the junctional area of the right superior caval vein and right atrium. In D and E the common pulmonary vein was found to connect very low in the right atrium close to where the left sinus horn enters the right atrial chamber. AS=atrial septum; LA=left atrium; leftPuV=left pulmonary veins; LSH=left sinus horn; LV=left ventricle; RA=right atrium; rightPuV=right pulmonary vein; RV=right ventricle; RVV=right venous valve