Table 1.
The IC50 of DEX (μM) and combination index (CI) in lymphoid tumor cell lines when treated with an appropriate concentration ratio of combined with Akt1 inhibitor, Akt2 inhibitor, or Akt1/2 inhibitor, respectively
| Lymphoid tumor cell line | The concentration ratio (DEX: Akt isoform inhibitors) | IC50 (DEX) | DEX+Akt1 | DEX+Akt2 | DEX+Akt1/2 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | CI | Synergistic interaction | IC50 | CI | Synergistic interaction | IC50 | CI | Synergistic interaction | |||
| CCRF-CEM | 1:1 | 0.3 | 0.18 | 0.59 | + | 0.13 | 0.27 | + + + | 0.03 | 0.15 | + + + + |
| CEM-DR | 150:1 | 138 | 55 | 0.87 | + - | 25 | 0.25 | + + + | 11 | 0.08 | + + + + |
| Jurkat | 250:1 | 224 | 208 | 1.2 | - | 74 | 0.38 | + + + | 63 | 0.39 | + + + |
| Daudi | 120:1 | 225 | 183 | 0.88 | + - | 213 | 0.97 | - | 118 | 0.73 | + |
A combination index (CI) below 1.0 indicates a synergistic interaction, equal to 1.0 indicates an additive interaction and greater than 1 indicates an antagonistic interaction28