Table 2.
Univariate and multivariate analyses of the new prognostic factors for progression-free survival.
| Variables | Univariable | Multivariable model 1 | Multivariable model 2 | ||||
|---|---|---|---|---|---|---|---|
| N (event) | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age ≥55 years | 101 (76) | 0.79 (0.56-1.13) | 0.204 | ||||
| Female gender | 34 (28) | 1.07 (0.69-1.65) | 0.770 | ||||
| Metachronous type | 61 (50) | 0.64 (0.44-0.92) | 0.015 | ||||
| Nephrectomy | 89 (72) | 0.48 (0.33-0.70) | <.001 | 0.48 (0.32-0.71) | <.001 | 0.48 (0.33-0.71) | <.001 |
| Body mass index | 145 (121) | 0.98 (0.92-1.04) | 0.500 | ||||
| KPS≤80 | 12 (11) | 1.10 (0.59-2.08) | 0.760 | ||||
| DFI≤1year | 106 (87) | 1.76 (1.20-2.58) | 0.004 | ||||
| mMSKCC, favorable | 48 (42) | 1 | (0.287) | ||||
| intermediate | 74 (59) | 1.38 (0.92-2.06) | 0.121 | ||||
| poor | 12 (10) | 1.34 (0.66-2.71) | 0.415 | ||||
| Heng, favorable | 14 (12) | 1 | (0.021) | ||||
| intermediate | 94 (77) | 2.00 (1.08-3.73) | 0.029 | ||||
| poor | 24 (20) | 2.84 (1.36-5.92) | 0.006 | ||||
| Lung metastasis | 113 (93) | 0.79 (0.53-1.16) | 0.228 | ||||
| Liver metastasis | 33 (26) | 1.23 (0.79-1.90) | 0.366 | ||||
| Bone metastasis | 54 (47) | 0.92 (0.64-1.32) | 0.652 | ||||
| Brain metastasis | 18 (16) | 1.30 (0.77-2.22) | 0.329 | ||||
| Hb, M<13, F<11.5 | 90 (70) | 1.30 (0.91-1.86) | 0.148 | ||||
| Platelet ≥400K | 19 (15) | 1.95 (1.12-3.39) | 0.018 | ||||
| Neutrophil ≥7500 | 28 (21) | 1.60 (0.99-2.57) | 0.054 | ||||
| Lymphocyte≥1500 | 60 (47) | 1.37 (0.95-1.98) | 0.097 | ||||
| NLR | 152 (125) | 1.03 (1.00-1.06) | 0.026 | 1.04 (1.00-1.07) | 0.029 | ||
| LDH ≥300 | 13 (12) | 1.72 (0.93-3.19) | 0.084 | ||||
| Corrected Calcium ≥10 | 11 (9) | 0.93 (0.46-1.85) | 0.832 | ||||
| Albumin <3.5 | 23 (16) | 1.78 (1.04-3.07) | 0.037 | ||||
| Alkaline phosphatase ≥104 | 50 (42) | 1.40 (0.96-2.07) | 0.085 | ||||
| AST≥40 | 12 (11) | 2.56 (1.36-4.84) | 0.004 | 1.96 (1.03-3.76) | 0.042 | ||
| ALT≥40 | 18 (15) | 1.26 (0.73-2.18) | 0.399 | ||||
| De Retis ratio | 148 (122) | 1.19 (0.97-1.45) | 0.096 | ||||
KPS, Karnofsky performance status score; DFI, disease-free interval; Hb, hemoglobin; NLR, neutrophil-to-lymphocyte ratio; LDH, lactate dehydrogenase; AST, aspartate transaminase; ALT, alanine transaminase; HR, hazard ratio; CI, confidence interval.
Multivariable model 1 (uni p-value ≤0.15 without LDH) used with metachronous type, nephrectomy, DFI<1, Hb, platelet, neutrophil, lymphocyte, albumin, Alkaline phosphatase, AST.
Multivariable model 2 (uni p-value ≤0.15 without LDH) used with metachronous type, nephrectomy, DFI<1, Hb, platelet, albumin, Alkaline phosphatase, NLR, de retis ratio.