Table 1. Cytotoxic Data of Compound 20 against NCI-60 Cell Lines.
|
20 |
||||
|---|---|---|---|---|
| cancer panel | cell line | GI50 | TGI | LC50 |
| leukemia | HL-60(TB) | 2.00 | 5.35 | >10 |
| K-562 | 1.82 | 9.08 | >10 | |
| MOLT-4 | 1.69 | 7.89 | >10 | |
| RPMI-8226 | 1.91 | 5.65 | >10 | |
| NSCLC | HOP-92 | 2.44 | 5.63 | >10 |
| NCI-H226 | 1.94 | 4.39 | >10 | |
| NCI-H460 | 2.79 | 8.27 | >10 | |
| NCI-H522 | 2.40 | 6.35 | >10 | |
| colon cancer | COLO 205 | 2.42 | 5.46 | >10 |
| HCT-116 | 1.73 | 3.56 | 7.33 | |
| HCT-15 | 1.56 | 4.17 | >10 | |
| SW-620 | 2.14 | 4.50 | >10 | |
| CNS cancer | SF-295 | 1.59 | 4.91 | >10 |
| SF-539 | 1.04 | 2.48 | 5.90 | |
| melanoma | LOX IMVI | 1.74 | 3.36 | 6.47 |
| MALME-3M | 1.80 | 4.13 | 9.48 | |
| SK-MEL-28 | 1.53 | 4.07 | >10 | |
| UACC-62 | 1.90 | 5.70 | >10 | |
| ovarian cancer | IGROV1 | 2.09 | 4.88 | >10 |
| OVCAR-3 | 1.92 | 3.79 | 7.47 | |
| SKOV-3 | 2.91 | 9.13 | >10 | |
| renal cancer | 786-0 | 1.30 | 2.80 | >10 |
| ACHN | 1.64 | 3.01 | 5.53 | |
| CAKI-1 | 1.87 | 3.76 | 7.57 | |
| RXF 393 | 1.41 | 2.94 | 6.14 | |
| TK-10 | 2.77 | 8.29 | >10 | |
| UO-31 | 1.61 | 2.98 | 5.54 | |
| prostate cancer | DU-145 | 2.01 | 4.13 | >10 |
| breast cancer | MCF7 | 1.78 | 4.26 | >10 |
| MDA-MB-231/ATCC | 2.60 | 7.34 | >10 | |
| BT-549 | 2.20 | 8.06 | >10 | |
| T-47D | 2.00 | 5.24 | >10 | |
| MDA-MB-468 | 1.95 | 4.27 | >10 | |