Table 1A:
Clinical and Laboratory Findings at the time of diagnosis of C3 Glomerulopathy
| Data Variable n=114 |
C3GN (n=102) |
DDD (n=12) |
|---|---|---|
| Age at diagnosis (years) | Mean (Std Dev): 41.5 (±22.1) Range: 3–85 |
Mean (Std Dev): 31.5 (±23.2) Range: 3–65 |
| Sex | Male: 60 (58.8%) Female: 42 (41.2%) |
Male: 3 (25%) Female: 9 (75%) |
| Race | White: 82 (80.4%) Black: 2 (2.0%) Asian: 3 (2.9%) American Indian/Alaskan Native: 1 (1.0%) Other: 4 (3.9%) Unknown: 10 (9.8%) |
White: 10 (83.3%) Black: 1 (8.3%) Asian: 0 American Indian/Alaskan Native: 0 Other: 0 Unknown: 1 (8.3%) |
| Ethnicity | Hispanic or Latino: 2 (2.0%) Non-Hispanic or Latino: 86 (84.3%) Unknown: 14 (13.7%) |
Hispanic or Latino: 0 Non-Hispanic or Latino: 10 (83.3%) Unknown: 2 (16.7%) |
| Blood Urea Nitrogen (mg/dL) | Median: 30, n=62 Range: 5.5–95.8 |
Median: 21; n=6 Range: 7–68 |
| Serum Creatinine (mg/dL) at diagnosis | Median: 1.6 Range: 0.3–14.7 |
Median: 1.4 Range: 0.3–6.3 |
| Serum albumin at diagnosis (g/dL) | Median: 3.4; n=56 Range: 1.2–4.6 |
Median: 2.7; n=8 Range: 1.7–3.9 |
| Hematuria | Positive: 89 (87.3%) Negative: 13 (12.7%) |
Positive: 11 (91.7%) Negative: 1(8.3%) |
| Proteinuria (mg/24 hours) |
Median: 2500 Range: 233–24,165 |
Median: 6478 Range: 496–17,867 |
|
Immunology Anti-GBM antibody ANCA/PR-3/MPO Anti-streptolysin Anti-DNase B ANA Anti-ds DNA Cryoglobulins Cryofibrinogen |
Positive: 0; Negative: 36; NA: 66 Positive: 3; Negative: 73; NA: 26 Positive: 2; Negative: 24; NA: 76 Positive: 1; Negative: 11; NA: 90 Positive: 11, Negative: 79; NA: 12 Positive: 5; Negative: 63; NA: 34 Positive: 3; Negative: 52; NA: 47 Positive: 0; Negative: 54; NA: 48 |
Positive: 0; Negative: 3; NA: 9 Positive: 0; Negative: 6; NA: 6 Positive: 1; Negative: 2; NA: 9 Positive: 0, Negative: 3; NA: 9 Positive:1; Negative: 7; NA: 4 Positive: 1; Negative: 4; NA: 7 Positive:0; Negative: 3; NA:9 Positive: 0; Negative: 2; NA: 10 |
|
Complement
C3 C4 |
Low: 43; Normal: 57; NA: 2 Low: 12; Normal: 86; NA: 4 |
Low: 7; Normal: 5 Low: 1; Normal: 11 |
Abbreviations: ANA: antinuclear antibody, ANCA, anti-neutrophil cytoplasmic antibodies; GBM, glomerular basement membrane; NA, not available; PR-3, anti-proteinase antibodies; MPO, anti-myeloperoxidase antibodies; Std Dev, standard deviation