Table 1.

Nucleotide and Amino Acid Changes During Passages

		Nucleotide									Amino Acid
Position*	ORFs	Position	C†	P1	P2	P3	P4	P5	P6	M‡	Position	C	P1	P2	P3	P4	P5	P6	M
372	ORF1	347	A	—§	C	C	C	C	C	—	116	Q	—	R	R	R	R	R	—
5,387	ORF2	197	C	—	—	—	T	T	T	—	66	P	—	—	—	S	S	S	—
5,387	ORF3	205	C	—	—	—	T	T	T	—	69	T	—	—	—	I	I	I	—

^*Nucleotide positions in the genomic RNA.

^†Sequence of the original G5 HEV.

^‡Monkey.

^§No exchange.