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. 2018 Dec 4;3(1):147–159. doi: 10.1002/hep4.1274

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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DKO gene signature indicates potential CAR activation. (A) Comparison of DKO and TC‐treated liver microarrays. Among 513 genes that were significantly changed in both microarrays, 347 genes (173 + 174, 67.6%) were regulated in the same manner. (B) KEGG pathway analysis of 347 genes; the top four gene categories in each analysis are shown. (C,D) Representative CYP and GST gene expressions (C) by TC treatment in WT and Car knockout (n = 4) as well as (D) in Fxr knockout, Shp knockout, and DKO (n = 3‐6). Student t test, *P < 0.05, ***P < 0.005 compared to CO‐treated WT. ANOVA followed by Tukey HSD; ##P < 0.01, ###P < 0.005. In some cases, the actual P value is presented.