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. 2018 Dec 4;3(1):147–159. doi: 10.1002/hep4.1274

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Loss of CAR accelerates cholestatic liver injury. (A) BW changes of WT, DKO, and TKO mice (n = 3‐5). (B) Representative image of whole body and liver at 3 months old. Scale bar, 10 mm; arrowhead, cholecystomegaly. (C) BW, liver weight, liver/BW ratio (%) (n = 8), and (D) gallbladder volume (n = 5) were measured. (E) Hematoxylin and eosin staining (magnification ×100) and KRT19 immunostaining (magnification ×40). ANOVA followed by Tukey HSD; #P < 0.05, ###P < 0.005. Abbreviations: GB, gallbladder; H&E, hematoxylin and eosin; LW, liver weight.