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. 2018 Dec 4;3(1):147–159. doi: 10.1002/hep4.1274

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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TKO further attenuates ABCB11‐mediated fecal BA excretion. (A) mRNA (n = 8) and (B) protein levels (n = 3) of ABCB11 were analyzed by q‐PCR and proteomics, respectively. Ratio (%) indicates the proportion of ABCB11 expressions compared to WT. (C) Immunostaining of ABCB11 (magnification ×200); arrowhead, residual canalicular ABCB11 expression. (D) BA levels in gallbladder‐collected bile (n = 4) and feces (n = 3). ANOVA followed by Tukey HSD, #P < 0.05, ###P < 0.005. Abbreviation: iFOT, intensity‐based fraction of total.