Table 3.
Altered metabolites after treatment of Alzheimer’s disease (AD) rats with ghrelin compared to AD group
| No. | Metabolite name | Chemical Shift (ppm) | Fold change | Direction |
|---|---|---|---|---|
| 1 | Homocysteine | 2.14, 2.85, 3.87 | 1.5 | ↓ |
| 2 | Lysine | 1.71, 1.89, 3.02,3.74 | 2.15 | ↓ |
| 3 | Lactate | 1.33, 4.11 | 2.15 | ↓ |
| 4 | Glycine | 3.54 | 1.8 | ↓ |
| 5 | Valine | 0.97, 1.02, 2.24, 3.57 | 2.27 | ↓ |
| 6 | Proline | 1.99, 2.05,3.34,3.45 | 1.6 | |
| 7 | Tyrosine | 3.06,6.87 | 1.9 | |
| 8 | 1-methyl Histidine | 7.05 | 1.67 | |
| 9 | 8-Hydroxyguanosine | 8.9-9.2(broad) | 6.2 | |
| 10 | Histidine | 7.02, 7.74 | 1.89 | |
| 11 | 3-Methylhistidine | 7.61 | 2.0 | |
| 12 | Phenylalanine | 3.26,3.97,7.33,7.38,7.43 | 1.8 |
a
Increased or decreased in the treated group compared to AD serum.