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Time course of changes in +dP/dt max, -dP/dt max, MAP, LVSP and LVEDP in apelin 40 μg/kg, after injection of saline (control) or different antagonists/inhibitors (n=8 in each group). Saline or antagonists/inhibitors were injected at min -10 and apelin at dose 40 µg/kg (or saline in panel I) at time 0. MAP: mean arterial pressure, LVSP: left ventricular systolic pressure, LVEDP: left ventricular end diastolic pressure. * = P<0.05, **=P<0.01 vs. zero time point
