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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Science. 2016 May 6;352(6286):aad6933. doi: 10.1126/science.aad6933

Fig. 5. The genome as a signaling platform.

Fig. 5.

(A) Proteins of the spindle assembly checkpoint (SAC; orange) bind via the kinetochore (blue) to mitotic chromosomes at centromeres. Upon binding of microtubules (MT) to kinetochores, SAC proteins are released and promote M-phase progression. (B) Topologically strained or highly condensed chromosome regions can be recognized by DNA damage sensors (red) and activate DNA damage response (DDR) pathways.