Table 1.
Demographics of EGFR, ALK, and ROS1 status in 407 NSCLC consecutive patients
| EGFR (n = 106) | ALK (n = 19) | ROS1 (n = 14) | |||||
|---|---|---|---|---|---|---|---|
| Variables | Total | N (%) | P † | N (%) | P † | N (%) | P † |
| Age, mean ± SD | 66.9 ± 12.07 | 64.8 ± 12.0 | 0.033 ‡ | 55.7 ± 15.7 | < 0.001 † | 61.2 ± 15.5 | < 0.001 † |
| Gender, N (%) | |||||||
| Male | 238 (58.6) | 29 (27.4) | < 0.001 | 7 (36.8) | 0.058 | 4 (28.6) | 0.026 |
| Female | 168 (41.4) | 77 (72.6) | 12 (63.2) | 10 (71.4) | |||
| Smoking history | |||||||
| Never smoker | 183 (46.4) | 76 (73.8) | < 0.001 | 14 (73.7) | 0.018 | 10 (71.4) | 0.098 |
| Ever smoker | 211 (53.6) | 27 (26.2) | 5 (26.3) | 4 (28.6) | |||
| Packyears | 19.5 ± 23.6 | 5.5 ± 11.6 | < 0.001 ‡ | 6.9 ± 14.8 | 0.001 ‡ | 12.1 ± 24.3 | 0.237‡ |
| Histology | |||||||
| ADC | 306 (75.4) | 101 (95.3) | < 0.001 § | 17 (89.5) | 0.179 § | 14 (100) | 0.026 § |
| SCC | 74 (18.2) | 4 (3.8) | 1 (5.3) | 0 (0.0) | |||
| ADSQ | 9 (2.2) | 1 (0.9) | 0 (0.0) | 0 (0.0) | |||
| Other NSCLCs | 17 (4.2) | 0 (0.0) | 1 (5.3) | 0 (0.0) | |||
| Stage | |||||||
| IA | 60 (15.2) | 20 (19.6) | < 0.001 ¶ | 2 (10.5) | 0.006 ¶ | 1 (7.1) | 0.001 ¶ |
| IB | 37 (9.4) | 10 (9.8) | 0 (0.0) | 1 (7.1) | |||
| IIA | 18 (4.6) | 7 (6.9) | 1 (5.3) | 0 (0.0) | |||
| IIB | 18 (4.6) | 2 (2.0) | 1 (5.3) | 1 (7.1) | |||
| IIIA | 38 (9.6) | 7 (6.9) | 2 (10.5) | 0 (0.0) | |||
| IIIB | 32 (8.1) | 6 (5.9) | 0 (0.) | 0 (0.0) | |||
| IV | 191 (48.5) | 50 (49.0) | 13 (68.4) | 11 (78.6) | |||
| Type of sample | |||||||
| Biopsy | 0.258†† | 1.000†† | 1.000†† | ||||
| Bronchoscopy | 42 (10.3) | 6 (5.7) | 3 (15.8) | 1 (7.1) | |||
| PCNB | 298 (73.4) | 87 (82.1) | 13 (68.4) | 9 (64.3) | |||
| Metastatic site | 35 (8.7) | 7 (6.6) | 3 (15.8) | 3 (21.4) | |||
| Cell block | 5 (1.2) | 3 (2.8) | 0 (0.0) | 1 (7.1) | |||
| EBUS‐TBNA | 10 (2.5) | 1 (0.9) | 0 (0.0) | 0 (0.0) | |||
| Surgical resection | |||||||
| Lobectomy | 13 (3.2) | 2 (1.9) | 0 (0.0) | 0 (0.0) | |||
| Wedge resection | 3 (0.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||
†
P value was evaluated compared to wild type for the gene.
‡
Evaluated by t‐test.
§
Adenocarcinoma versus all others.
¶
Stage I–IIIa versus IIIb–IV.
††
Biopsy versus surgical resection.
Values in bold are statistically significant.
ADC, adenocarcinoma; SCC, squamous cell carcinoma; ADSQ, adeno‐squamous carcinoma; NSCLC, non‐small cell lung cancer; PCNB, percutaneous needle aspiration biopsy; EBUS‐TBNA, endobronchial ultrasound‐transbronchial needle aspiration biopsy.