Table 1.
Untargeted metabolomics identifies multiple intermediates in histidine metabolism in plasma and urine for patients with urocanic aciduria. z-Scores are shown.
| Compound | Plasma |
Urine |
||
|---|---|---|---|---|
| z-Score |
z-Score |
|||
| Subject 1 | Subject 2 | Subject 1 | Subject 2 | |
| trans-Urocanate | 7.0939 | 6.8137 | 7.7051 | 7.5464 |
| cis-Urocanate | 5.7492 | 5.2359 | 3.1651 | 3.2677 |
| Imidazole propionate | 3.7030 | 3.2626 | 2.5705 | 2.4829 |
| 1-methylhistidine | 1.7940 | 1.6233 | 1.8154 | 0.6895 |
| beta-Alanine | 1.0711 | 0.2461 | 1.2420 | 0.5525 |
| Imidazole lactate | 1.0099 | 0.1857 | 0.3640 | −0.3691 |
| 1-methylhistamine | NA | NA | 0.0476 | −0.8100 |
| 4-imidazoleacetate | 0.5374 | 1.0653 | −0.1010 | −0.8854 |
| Histidine | 0.1381 | −1.7535 | −0.3511 | −1.3456 |
| Glutamate | 0.929 | 0.123 | −1.2165 | −2.0166 |
| 1-methylimidazoleacetate | −1.4329 | −0.7770 | −1.6684 | −2.2551 |
| Hydantoin-5-propionic acid | NA | NA | −2.2781 | −2.1873 |
| Homocarnosine | NA | NA | −2.9191 | NA |