Table 3. In vitro activities of the antimicrobial agents tested against the 135 Streptococcus pneumoniae isolates.
Antibiotic | MIC50 | MIC90 | Range | S (%) | I (%) | R (%) |
---|---|---|---|---|---|---|
Penicillin | 0.032 | 0.75 | <0.016–4 | 65.2 | 27.4 | 7.4 |
Amoxicillin | 0.032 | 2 | 0.016–64 | 90.4 | 5.9 | 3.7 |
Cefuroxime | 0.047 | 2 | 0.016–12 | 80 | 6.7 | 13.3 |
Cefotaxime | 0.047 | 0.75 | <0.016–8 | 95.6 | 2.2 | 2.2 |
Cefepime | 0.19 | 1 | 0.016–8 | 91.2 | 4.4 | 4.4 |
Imipenem | 0.047 | 0.125 | 0.002–3 | 91.9 | 5.9 | 2.2 |
Meropenem | 0.047 | 0.25 | 0.002–3 | 92.6 | 5.9 | 1.5 |
Erythromycin | 0.064 | ≥256 | 0.016–≥256 | 69.6 | - | 30.4 |
Clindamycin | 0.064 | ≥256 | 0.016–≥256 | 84.4 | - | 15.6 |
Ciprofloxacin | 0.75 | 1 | 0.023–≥32 | 97.8 | - | 2.2 |
Levofloxacin | 0.75 | 1 | 0.032–≥32 | 98.5 | - | 1.5 |
Moxifloxacin | 0.125 | 0.19 | 0.016–≥32 | 98.5 | - | 1.5 |
Chloramphenicol | 2 | 3 | 0.19–12 | 98.5 | - | 1.5 |
Tetracycline | 0.25 | 32 | 0.047–≥256 | 83.7 | - | 16.3 |
TMP/SMX | 0.094 | 2 | 0.012–≥32 | 83.7 | 8.9 | 7.4 |
Vancomycin | 0.38 | 0.5 | 0.016–1 | 100 | - | 0.0 |
Linezolid | 0.75 | 1 | 0.023–2 | 100 | - | 0.0 |
Quinupristin/dalfopristin | 0.38 | 1 | 0.125–4 | 91.1 | 5.9 | 3 |
Tigecycline | 0.047 | 0.25 | 0.016–1.5 | 99.3 | - | 0.7 |
Daptomycin | 0.094 | 0.125 | 0.016–0.75 | 100 | - | 0.0 |
S, susceptible; I, intermediate; R, resistant; TMP/SMX, trimethoprim-sulfamethoxazole.