Skip to main content
. 2018 Dec 31;1(6):e201800118. doi: 10.26508/lsa.201800118

Figure 8. GAK function in cargo trafficking.

Figure 8.

(A) A simplified model of GAK function during NKA cargo transport. (1) AP-1 and clathrin mediate transport from the Golgi to the plasma membrane during which Atp1a3 T705 may be phosphorylated by GAK. (2) AP-2 and clathrin mediate the endocytosis of NKA. During uncoating, phosphorylation of Atp1a3 T705 may occur. (3) Under basal conditions, GAK phosphorylates NKA at Atp1a3 T705, and NKA is recycled to plasma membrane. (4) Without T705 phosphorylation, NKA is preferentially localized to EEA1 containing early endosomes.