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. 2018 Nov 12;41(2):765–778. doi: 10.3892/or.2018.6864

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Comet assay. (A) HeLa and SiHa cells were treated by 1× IC₅₀ or 2× IC₅₀ icaritin and/or vehicle control for 24 h and a comet assay was used to identify DNA strand breaks (scale bar, 200 µm). (B) Quantification of tail moment. Tail moment was defined as percentage of tail DNA × tail length and was quantified using the CASP software (n=40; ***P<0.001). (C) Inhibition of DNA strand breaks by NAC. HeLa and SiHa cells with or without pre-incubation (1 h) with 5 mM NAC were treated by icaritin for 24 h (***P<0.001). IC₅₀, half maximal inhibitory concentration; OGG, 8-oxoguanine glycosylase; NAC, N-acetyl cysteine; NS, not significant.