Table I.

GO analysis of differentially expressed genes associated with glioblastoma.

A, upregulated genes
Term	Count	%	P-value	FDR
GO:1903047: Mitotic cell cycle process	80	17.699	9.95×10−25	1.90×10−21
GO:0000278: Mitotic cell cycle	83	18.362	2.43×10−24	4.64×10−21
GO:0022402: Cell cycle process	98	21.681	2.27×10−23	4.35×10−20
GO:0007049: Cell cycle	107	23.672	1.40×10−21	2.68×10−18
GO:0051301: Cell division	59	13.053	7.57×10−21	1.45×10−17
GO:0007067: Mitotic nuclear division	48	10.619	2.22×10−18	4.25×10−15
GO:0044770: Cell cycle phase transition	54	11.946	2.47×10−18	4.72×10−15
GO:0044772: Mitotic cell cycle phase transition	52	11.504	4.17×10−18	7.96×10−15
GO:0000819: Sister chromatid segregation	35	7.743	5.93×10−18	1.13×10−14
GO:0000280: Nuclear division	52	11.504	9.96×10−16	1.91×10−12
B, downregulated genes
Term	Count	%	P-value	FDR
GO:0099537: Trans-synaptic signaling	137	16.707	1.13×10−64	2.15×10−61
GO:0098916: Anterograde trans-synaptic signaling	137	16.707	1.13×10−64	2.15×10−61
GO:0099536: Synaptic signaling	137	16.707	1.13×10−64	2.15×10−61
GO:0007268: Chemical synaptic transmission	137	16.707	1.13×10−64	2.15×10−61
GO:0007399: Nervous system development	227	27.682	4.23×10−45	8.05×10−42
GO:0007267: Cell-cell signaling	178	21.707	9.70×10−41	1.85×10−37
GO:0050804: Modulation of synaptic transmission	66	8.048	1.69×10−31	3.21×10−28
GO:0048666: Neuron development	124	15.121	2.61×10−31	4.98×10−28
GO:0031175: Neuron projection development	111	13.536	5.22×10−30	9.94×10−27
GO:0007610: Behavior	90	10.975	9.43×10−30	1.80×10−26

FDR, false discovery rate; GO, gene ontology.