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. 2018 Sep 28;17(1):697–705. doi: 10.3892/ol.2018.9526

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Figure 3. — Effects of resveratrol were diminished in PC3 cells expressing a stable HIF-1α mutant. (A) HIF-1α in cells expressing wt or mutant HIF-1α in normoxic conditions. (B) Cellular respiration rates and (C) mitochondrial network characteristics in cells expressing mutant HIF-1α and treated with either 10 µM RES or vehicle control (DMSO) for 48 h. (D) Population doubling time and (E) cell cycle distribution for cells expressing mutant HIF-1α. In (B-E) open bars are DMSO vehicle control and filled bars are 10 µM RES. Data shown are means ± SEM of (A) 4; (B) 5–6; (C) 44; (D) 9 and (E) 6 independent measurements. *P<0.05 RES-treated vs. DMSO-treated cells; ^‡P<0.05 wtHIF-1α vs. mutHIF-1α.

Figure 3. — Effects of resveratrol were diminished in PC3 cells expressing a stable HIF-1α mutant. (A) HIF-1α in cells expressing wt or mutant HIF-1α in normoxic conditions. (B) Cellular respiration rates and (C) mitochondrial network characteristics in cells expressing mutant HIF-1α and treated with either 10 µM RES or vehicle control (DMSO) for 48 h. (D) Population doubling time and (E) cell cycle distribution for cells expressing mutant HIF-1α. In (B-E) open bars are DMSO vehicle control and filled bars are 10 µM RES. Data shown are means ± SEM of (A) 4; (B) 5–6; (C) 44; (D) 9 and (E) 6 independent measurements. *P<0.05 RES-treated vs. DMSO-treated cells; ^‡P<0.05 wtHIF-1α vs. mutHIF-1α.