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. 2018 Nov 9;41(2):779–788. doi: 10.3892/or.2018.6860

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Downregulation of CDK5 in GC cells promotes metastasis. (A) HGC-27 cells with CDK5 stably knocked down and control cells were generated. (B) The proliferation of shCDK5 and control cells was measured by CCK-8 and SRB. (C) Colony formation assays were performed to assess the ability of the shCDK5 and control cells to form colonies. (D) Transwell assays revealed that knockdown of CDK5 in HGC-27 GC cells promoted metastasis. Crystal violet staining. Magnification, ×200. **P<0.01, as indicated. CDK5, cyclin dependent kinase 5; CCK-8, Cell Counting Kit-8; SRB, Sulforhodamine B; GC, gastric cancer; sh-, short hairpin RNA; Scr, scramble.