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. 2018 Nov 9;41(2):779–788. doi: 10.3892/or.2018.6860

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Inhibition of PP2A antagonizes the metastasis of CDK5-overexpressing GC cells. (A) CCK-8 and SRB assays demonstrated that inhibition of PP2A did not significantly affect proliferation. (B) Inhibition of PP2A antagonized the metastasis of CDK5-overexpressing GC cells (magnification, ×200). (C) Western blotting of PP2A knockdown in CDK5 knockdown (shCDK5 #1) HGC-27 cells. (D) Knockdown of PP2A in CDK5 knockdown HGC-27 cells reduced metastasis (magnification, ×200). (E) CCK-8 and SRB assays demonstrated that knockdown of PP2A in CDK5 knockdown HGC-27 cells did not significantly affect proliferation. CDK5, cyclin dependent kinase 5; PP2A, serine/threonine-protein phosphatase 2A; CCK-8, Cell Counting Kit-8; GC, gastric cancer; sh-, short hairpin RNA; Scr, scramble; EGFP, enhanced green fluorescent protein; WT, wild-type; SRB, Sulforhodamine B; DOX, doxycycline; OA, Okadaic Acid.