The Oxygen-laden MSC-hemo group significantly enhances the effect of chemotherapeutic treatments on gastric cancer cells. (A) 5-fu treatment group for the MKN45 and SGC-7901 cells. It demonstrated that the oxygen-laden MSC-hemo group significantly enhanced the effect of 5-fu treatment on MKN45 and SGC-7901 cells, while the MSC group had no significant difference, compared with the control group. (B) CDDP treatment group for the MKN45 and SGC-7901 cells. It demonstrated that the oxygen-laden MSC-hemo group significantly enhanced the effect of CDDP treatment on MKN45 and SGC-7901 cells, while the MSC group had no significant difference, compared with the control group. *P>0.05, compared with MSC+5-fu or MSC+CDDP; **P<0,05, compared with oxygen-laden MSC-hemo+5-fu or oxygen-laden MSC-hemo+CDDP. MSCs, mesenchymal stem cells; CDDP, cisplatin; 5-fu, 5-fluroouracil.