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. 2018 Nov 8;17(1):1237–1244. doi: 10.3892/ol.2018.9676

Figure 5.

Figure 5.

N-cadherin was involved in SIRT6 mediated proliferation and invasion of OS cells. (A) RT-qPCR was performed to determine the mRNA level of N-cadherin in SAOS-2 cells or (B) MG-63 cells transfected with control siRNA or Si-N-cadherin#1, or Si-N-cadherin#2. GAPDH was used as an internal reference. **P<0.01 vs. NC. (C) The MTT assay (D) The Transwell assay was carried out in SAOS-2 cells or MG-63 cells transfected with control siRNA or Si-SIRT6#1 or co-transfected with Si-SIRT6#1 and control siRNA or Si-N-cadherin. *P<0.05 vs. NC. SIRT6, sirtuin-6; OS, osteosarcoma; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.