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Overexpression of PTEN inhibits cell proliferation in lung cancer cell lines. (A) A549 and (B) SK-MES-1 cells were transfected with pcDNA3.1-PTEN plasmid and pcDNA3.1 (+) plasmid for 24 h and PTEN expression was detected using western blotting. Cells were cultured for 24, 48 and 72 h. Cell viability was determined in (C) A549 and (D) SK-MES-1 cells. *P<0.05 and **P<0.01 vs. Ctrl. plasmid-transfected cells. PTEN, phosphatase and tensin homolog; Ctrl., control; OD, optical density.
