Table I.
Expression of miRNA-126-3p and miRNA-126-5p in LUAD according to RT-qPCR data.
| miRNA-126-3p | miRNA-126-5p | ||||||
|---|---|---|---|---|---|---|---|
| Clinicopathological parameters | N | Mean ± SD | t | P-value | Mean ± SD | t | P-value |
| Tissue | |||||||
| LUAD | 101 | 3.511±2.118 | −8.003 | <0.001 | 4.271±2.501 | −4.970 | <0.001 |
| Adjacent normal lung tissue | 101 | 6.674±3.362 | 6.314±3.289 | ||||
| Sex | |||||||
| Male | 56 | 3.619±2.157 | 0.572 | 0.569 | 4.487±2.359 | 0.975 | 0.332 |
| Female | 45 | 3.376±2.083 | 4.000±2.670 | ||||
| Age (years) | |||||||
| <60 | 41 | 3.549±1.897 | 0.149 | 0.881 | 4.194±2.081 | ||
| ≥60 | 60 | 3.484±2.271 | 4.323±2.535 | ||||
| Smoking history | |||||||
| + | 18 | 4.306±1.949 | 1.930 | 0.060 | 4.689±2.439 | −0.602 | 0.500 |
| − | 26 | 3.192±1.833 | 5.141±2.451 | ||||
| Tumor size (cm) | |||||||
| ≤3 | 53 | 3.373±2.250 | −0.685 | 0.495 | 4.450±2.665 | 0.755 | 0.452 |
| >3 | 48 | 3.663±1.974 | 4.073±2.319 | ||||
| Vascular invasion | |||||||
| + | 31 | 3.074±1.697 | −1.384 | 0.169 | 3.045±1.544 | −4.195 | <0.001 |
| − | 70 | 3.704±2.263 | 4.814±2.657 | ||||
| LNM | |||||||
| + | 56 | 3.161±1.679 | −1.798 | 0.076 | 3.671±2.090 | −3.197 | 0.002 |
| − | 45 | 3.946±2.514 | 5.142±2.713 | ||||
| TNM stage | |||||||
| I + II | 44 | 4.140±2.583 | 2.542 | 0.013 | 4.923±2.700 | 2.296 | 0.024 |
| III + IV | 57 | 3.025±1.527 | 3.769±2.233 | ||||
| Pathological grade | |||||||
| I | 17 | 3.482±2.323 | F=1.2 | 0.305 | 4.147±2.543 | F=1.3 | 0.271 |
| II | 61 | 3.735±2.087 | 4.565±2.629 | ||||
| III | 23 | 2.935±2.024 | 3.583±2.034 | ||||
LUAD, lung adenocarcinoma; N, number of samples; SD, standard deviation; t, t-value of Student's t-test; F, analysis of variance; LNM, lymph node metastasis; +, positive; -, negative.