Table III.

GO functional annotation of the 335 target genes.

GO ID	Term	Count	P-value	Gene symbol
Biological process
GO:0007267	Cell-cell signaling	31	4.43E-07	FGF5, GRIK2, HOXA11, OPRK1, EFNA2, GLRA3, GREM1, IL11, PCSK1, KCNQ5, NPTX1, BARX1, IL17A, and others
GO:0045165	Cell fate commitment	13	8.31E-06	ONECUT1, HOXA11, ONECUT2, NEUROG2, PAX2, VSX2, NR2E1, DLX1, WNT3, NEUROD1, NEUROD4, GAP43, TLX1
GO:0060348	Bone development	11	7.90E-05	PTHLH, CYP24A1, CASR, CYP27B1, TNFSF11, HOXA11, COL2A1, COL1A1, COL5A2, IGFBP3, MMP13
Molecular function
GO:0005887	Integral to plasma membrane	43	2.07E-05	MCHR1, CASR, SCN3A, GRIK2, ENPP3, OPRK1, GLRA3, ITGA11, PCDHA1, KCNJ13, KCNQ5, UGT1A8, and others
GO:0034702	Ion channel complex	15	2.35E-05	KCND2, SCN3A, GLRA3, CACNG7, CACNA1I, GABRA5, KCTD4, KCNJ13, KCNQ5, KCNQ3, CHRNA5, and others
GO:0031226	Intrinsic to plasma membrane	43	3.52E-05	MCHR1, CASR, SCN3A, GRIK2, ENPP3, OPRK1, GLRA3, ITGA11, PCDHA1, KCNJ13, KCNQ5, UGT1A8, KCNQ3, and others
Cell component
GO:0015267	Channel activity	23	7.61E-06	KCND2, TRPM8, SCN3A, TRPC5, GRIK2, GLRA3, CACNG7, GABRA5, TRPA1, CACNA1I, GRIA4, CNGB3, KCTD4, and others
GO:0022803	Passive transmembrane transporter activity	23	7.90E-06	KCND2, TRPM8, SCN3A, TRPC5, GRIK2, GLRA3, CACNG7, GABRA5, TRPA1, CACNA1I, GRIA4, CNGB3, KCTD4, and others
GO:0005216	Ion channel activity	22	9.34E-06	KCND2, TRPM8, SCN3A, TRPC5, GRIK2, GLRA3, CACNG7, GABRA5, TRPA1, CACNA1I, GRIA4, CNGB3, KCTD4, and others

GO, Gene Ontology.