Table I.

Overview of SIRT1 functions.

Author, year	Function	Substrates	Effects of SIRT1	(Refs.)
Peters et al, 2001	Genomic stability	H3K9Ac, H4K16Ac,	Modification of chromatin through the	(11)
Vaquero et al, 2004		H1K26Ac, Suv39h1,	formation of heterochromatin structure	(12)
Vaquero et al, 2007		TERT	and positive regulation of telomere length	(13)
Palacios et al, 2010				(14)
Wang et al, 2008	DNA repair	γ-H2AX, BRCA1,	Induction of HR and NHEJ-mediated DNA	(4)
Sawada et al, 2003		Rad51, MRN complex,	repair	(17)
Yuan et al, 2007		Ku70, Bax	Induction of formation of NBSI (nibrin) foci	(15)
Jeong et al, 2007			and direct recruitment to DNA damage sites	(16)
			Induction of Ku70-dependent DNA repair signalling
Brunet et al, 2004	Stress response	p53, Foxo3a, p300,	Inhibition of apoptosis and promote DNA	(18)
Motta et al, 2004		set7/9, MnSOD	repair by deacetylase p53	(20)
Kobayashi et al, 2005			Promotion of cell survival during oxidative	(19)
Chua et al, 2005			stress by inducing DNA repair in cooperation	(21)
Yi et al, 2010			with Foxo1	(22)
Peng et al, 2011	DNA methylation	DNMT1, DNMT3b	Alteration of DNMTs enzymatic activity by deacetylating different lysines	(23)

H3K9ac, histone H3 lysine 9 acetylation; H4K16ac, histone H4 lysine 16 acetylation; H1K26ac, histone H1 lysine 26 acetylation; Suv39h1, suppressor of variegation 3–9 homolog 1; TERT, telomerase reverse transcriptase; γ-H2AX, phosphorylated form of variant histone H2AX; BRCA1, breast cancer type 1 susceptibility protein; Rad51, DNA repair protein Rad51 homolog 1; MRN complex, Mre11-Rad50-Nbs1 complex; Ku70, X-ray repair cross-complementing 6; Bax, BCL2 associated × protein; HR, homologous recombination; NHEJ, nonhomologous end joining; Foxo3a, forkhead box o3 α; p300, E1A binding protein p300; Set7/9, Set domain containing lysine methyltransferase 7; MnSOD, manganese-containing superoxide dismutase; Foxo1, forkhead box protein o1; DNMT1, DNA methyltransferase 1; DNMT3b, DNA methyltransferase 3 β.