Table III.
Regulatory role of SIRT1 in oral cancer.
| Author, year | Type of function | Role of SIRT1 | (Refs.) |
|---|---|---|---|
| Chen et al, 2014 | Tumour suppressor | Maintenance of epithelial polarity by increases the expression of | (5) |
| Kang et al, 2017 | E-cadherin | (6) | |
| Murofushi et al, 2017 | Suppression of expression of N-cadherin and vimentin | (7) | |
| Downregulation of genes involved in migration and invasion, such as | |||
| CSK2A2, FRA1, ACTB, and SLUG | |||
| Downregulation of TGF-β downstream targets | |||
| Induction of p21 and G1/S phase cell cycle arrest | |||
| Xiong et al, 2011 | Tumour promoter | Induction of cisplatin resistance by increasing the expression of annexin A4, stathmin, SOD2 and thioredoxin | (8) |
| Induction of growth and survival of cancerous cells |
SOD2, superoxide dismutase 2; CSK2A2, casein kinase II subunit α; FRA1, fos related antigen 1; ACTB, beta-actin; SLUG, snail family transcriptional repressor 2, TGF-β, transforming growth factor β.