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. 2018 Nov 12;17(1):1080–1088. doi: 10.3892/ol.2018.9692

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Copyright: © Ushio et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — miRNA-target regulatory interaction network. (A) miRNA-target regulatory network merged with the tumor suppressor genes protein interaction network. The red squares indicate miRNA nodes [(A) miR-383; (B) miR-204]. Black circles indicate targets (mRNAs) of single miRNAs, purple circles indicate targets shared by miRNAs and blue circles indicate tumor suppressor genes predicted to be targeted by one or both of the miRNA. The edges (lines) connecting two nodes are indicative of regulation (interaction). (B) Separated co-ordinate network showing the interactions between microRNAs and tumor suppressor genes. The node colors indicate the CV; pink gradient indicates CVs lower than average, blue gradient indicates CVs higher than average. Edge width indicates the betweenness measurement. miR/miRNA, microRNA; CV, centroid value.

Figure 2. — miRNA-target regulatory interaction network. (A) miRNA-target regulatory network merged with the tumor suppressor genes protein interaction network. The red squares indicate miRNA nodes [(A) miR-383; (B) miR-204]. Black circles indicate targets (mRNAs) of single miRNAs, purple circles indicate targets shared by miRNAs and blue circles indicate tumor suppressor genes predicted to be targeted by one or both of the miRNA. The edges (lines) connecting two nodes are indicative of regulation (interaction). (B) Separated co-ordinate network showing the interactions between microRNAs and tumor suppressor genes. The node colors indicate the CV; pink gradient indicates CVs lower than average, blue gradient indicates CVs higher than average. Edge width indicates the betweenness measurement. miR/miRNA, microRNA; CV, centroid value.