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. 2018 Nov 27;41(2):917–927. doi: 10.3892/or.2018.6888

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Downregulation of KDM2A suppresses cell migration and invasion of the A2780 and SKOV3 cells. (A and B) The 3 cell groups were collected and assayed for their capabilities of invasion using a Transwell system. Cell invasion of the sh-KDM2A was significantly decreased compared to the 2 control groups. Scale bar, 50 µm. (C and D) The 3 cell groups were calculated for cell migration using the wound healing assay. Cells in the sh-KDM2A group had decelerated scratch wound healing ability. Scale bar, 50 µm. (E) Western blot analysis was used to assess the changes in MMP2 and MMP9 in the 3 groups. The levels of both proteins were decreased in the sh_KDM2A groups. *P<0.05, **P<0.01.