Table 2.
Levels of tNAA and Glx in Perisylvian Cortices
| Left Inferior Frontal Cortex | Right Inferior Frontal Cortex | |||
|---|---|---|---|---|
| Methamphetamine | Control | Methamphetamine | Control | |
| tNAA | 8.2±1.2 | 8.1±1.0 | 8.2±1.0 | 8.2±0.9 |
| Participants | 41 | 44 | 37 | 41 |
| Glx | 12.4 ± 2.2 | 12.8±2.2 | 12.7±2.5* | 14.0±2.4 |
| Left insula | Right insula | |||
| Methamphetamine | Control | Methamphetamine | Control | |
| tNAA | 8.4±1.3** | 7.7±0.9 | 7.8±1.0 | 8.1±2.1 |
| Participants | 31 | 31 | 37 | 37 |
| Glx | 9.8±2.7 | 9.3±2.0 | 9.3±2.0* | 10.6±3.5 |
Indicated are numbers of participants with usable MRSI data for each metabolite in each target brain region.
tNAA and Glx levels are group means±SD in IU, corrected for voxel CSF content.
Significant between-group comparisons in bold (*P<.05, **P<.01 Bonferroni-corrected for multiple comparisons, ANCOVA covarying for age, sex, tobacco-smoking status, marijuana use status, and white and gray matter content).