Table II.
Kyoto Encyclopedia of Genes and Genomes pathway analysis of DEGs associated with osteoporosisa.
| Category of DEGs | Term | Countb | %c | P-value | Genes |
|---|---|---|---|---|---|
| Upregulated | hsa04080:Neuroactive ligand-receptor interaction | 28 | 3.63 | 2.34×10−7 | AVPR2, MCHR1, GRIK2, NPY2R, GRIK3, GABRB1, F2RL1, GRIK5, HCRTR1, LTB4R, CNR1, P2RY1, CHRNA4, GRID1, GABRG3, GABRA2, PTGER3, NPBWR2, LEP, P2RY10, ADRB1, GRM2, PRLR, GRM8, CHRM1, P2RX2, GHSR, TSHR |
| hsa04015:Rap1 signaling pathway | 19 | 2.46 | 1.45×10−4 | PIK3CG, ADCY1, MAGI2, PGF, EFNA2, SIPA1L2, KITLG, FGF23, RGS14, PRKCB, CNR1, P2RY1, RASGRP2, CALML6, RAPGEF3, ANGPT2, RAPGEF1, AKT2, ITGA2B | |
| hsa04024:cAMP signaling pathway | 16 | 2.07 | 0.002 | PIK3CG, HCN2, ADCY1, PTGER3, CFTR, CNGB1, CNGB3, ADRB1, CHRM1, CAMK2D, CALML6, RAPGEF3, GHSR, CAMK2A, TSHR, AKT2 | |
| hsa04724:Glutamatergic synapse | 11 | 1.42 | 0.004 | SLC17A8, SLC1A2, ADCY1, DLGAP1, GRM2, GRM8, GRIK2, GRIK3, GRIK5, SHANK3, PRKCB | |
| hsa04261:Adrenergic signaling in cardiomyocytes | 11 | 1.42 | 0.020 | PIK3CG, ADCY1, ADRB1, CACNG8, PPP1R1A, CACNB1, CAMK2D, CALML6, RAPGEF3, CAMK2A, AKT2 | |
| Downregulated | hsa05200:Pathways in cancer | 7 | 55.00 | 0.030 | FGFR2, LAMA4, WNT4, HSP90B1, APC2, PIAS2, CDK2 |
a
The top 5 terms were selected for upregulated DEGs and one term was selected for downregulated DEGs according to P-values.
b
Count is the number of enriched genes for each term. DEGs, differentially expressed genes.
c
Represents the percentage of genes contained in each term to the upregulated or downregulated genes.