Table III.
Summary of ClueGO analysis of DEGs for biological processes associated with osteoporosisa.
| DEG expression | GO ID | GO term | Genes, nb | %c | P-value | Genes |
|---|---|---|---|---|---|---|
| Upregulated | GO:0007275 | Multicellular organism | 220 | 4.14 | 5.03×10−7 | ADAMTS9, ADCY1, AKT2, ALG5, AMOT, ANGPT2, ANKRD54, ANPEP, APLP1, APOH, AQP1, ARHGAP26, ASB4, ASCL2, ASNS, ATCAY, ATN1, AVPR2, AXIN2, BCAN, BMP7, BMP8B, BRSK1, BRSK2, CAMK2A, CAMK2D, CBX2, CCK, CCR4, CD24, CD74, CHRM1, CNGB1, CNR1, CNTN4, COL10A1, CPB2, CUX2, CYP19A1, DACH1, DCHS2, DDC, DMBX1, DNAH11, DRAXIN, DYRK1B, EFNA2, EGR2, EMX1, EN2, EPHA4, ESRRB, EZH1, F2RL1, FEZF2, FGF23, FOXE1, FOXG1, FOXO1, FOXP2, FZD10, GABRB1, GAL, GHSR, GJA5, GJB6, GPM6B, GPRC5B, HDAC10, HES4, HID1, HIPK1, HMGA2, HNF4A, HOOK1, HPRT1, HSPB6, HTN3, IBSP, IKZF1, IKZF3, IL2, IRF4, ITGA2B, JMJD6, JPH1, KCNIP2, KITLG, KLHL17, KLHL32, KLKB1, KMT2B, KRT40, LEP, LFNG, LHX2, LHX6, LHX8, LPAL2, LRRC7, LSAMP, LST1, LTBP4, LYL1, MAB21L2, MAGI2, MARK4, MCF2, MEF2D, MEX3C, MINK1, MMP11, MOBP, MOV10L1, MT1G, MYCBPAP, MYH7B, MYO3B, MYO7A, NDRG2, NEUROG2, NFATC4, NME8, NOBOX, NPAS1, NPPC, NPY2R, NR0B1, NR2F6, NRP2, NRXN1, NTRK3, OBSL1, OLFM1, P2RX2, P2RY1, PAK3, PCDH15, PCDH8, PCDHGC5, PCSK6, PCYT1B, PECAM1, PGF, PHOSPHO1, PIK3CG, PKP2, PLCG2, POLB, PPARGC1A, PPARGC1B, PPDPF, PRKCB, PRLR, PSG1, PTPRB, RAB11FIP4, RAD21L1, RAPGEF1, RAPGEF3, RARRES2, RAX, RFX4, RGS14, RIMS1, RIPPLY2, SCEL, SCN3B, SCRT1, SDK2, SEMA4D, SEMA6B, SERPINA5, SETDB2, SEZ6L, SF1, SFTPD, SH3TC2, SHANK3, SHOX, SIAH3, SIN3A, SLC17A8, SLC1A2, SLC8A3, SMIM6, SOST, SOX10, SOX2, SOX8, SPATA19, ST8SIA2, STMN4, STOX1, TAF10, TBX3, TBX6, TCF21, TEF, TERT, TEX11, THPO, TIE1, TNFRSF11A, TP63, TRIB1, TRIM54, TRPC6, TRPM1, TSHR, TSSK1B, TTPA, TUB, UBE4B, WDR72, WT1, XIRP2, ZFP36L1, ZFP36L2, ZFP42 |
| GO:0048731 | System development | 203 | 4.28 | 1.94×10−7 | ADAMTS9, ADCY1, AKT2, AMOT, ANGPT2, ANKRD54, ANPEP, APLP1, APOH, AQP1, ARHGAP26, ASB4, ASCL2, ASNS, ATCAY, ATN1, AVPR2, AXIN2, BCAN, BMP7, BMP8B, BRSK1, BRSK2, CAMK2A, CAMK2D, CCK, CCR4, CD24, CD74, CHRM1, CNGB1, CNR1, CNTN4, COL10A1, CPB2, CUX2, CYP19A1, DCHS2, DMBX1, DNAH11, DRAXIN, DYRK1B, EFNA2, EGR2, EMX1, EN2, EPHA4, ESRRB, EZH1, F2RL1, FEZF2, FGF23, FOXE1, FOXG1, FOXO1, FOXP2, FZD10, GABRB1, GAL, GHSR, GJA5, GJB6, GPM6B, GPRC5B, HDAC10, HES4, HID1, HIPK1, HMGA2, HPRT1, HSPB6, HTN3, IBSP, IKZF1, IKZF3, IL2, IRF4, ITGA2B, JMJD6, JPH1, KCNIP2, KITLG, KLHL17, KLHL32, KLKB1, KMT2B, KRT40, LEP, LFNG, LHX2, LHX6, LHX8, LPAL2, LRRC7, LSAMP, LST1, LYL1, MAB21L2, MAGI2, MARK4, MCF2, MEF2D, MEX3C, MINK1, MOBP, MT1G, MYH7B, MYO3B, MYO7A, NDRG2, NEUROG2, NFATC4, NOBOX, NPAS1, NPPC, NPY2R, NR0B1, NR2F6, NRP2, NRXN1, NTRK3, OBSL1, OLFM1, P2RX2, P2RY1, PAK3, PCDH15, PCDH8, PCDHGC5, PCSK6, PCYT1B, PECAM1, PGF, PHOSPHO1, PIK3CG, PKP2, PLCG2, POLB, PPARGC1A, PPARGC1B, PPDPF, PRKCB, PRLR, PSG1, PTPRB, RAB11FIP4, RAD21L1, RAPGEF1, RAPGEF3, RARRES2, RAX, RFX4, RGS14, RIMS1, RIPPLY2, SCEL, SCN3B, SCRT1, SDK2, SEMA4D, SEMA6B, SERPINA5, SETDB2, SEZ6L, SF1, SFTPD, SH3TC2, SHANK3, SHOX, SIN3A, SLC17A8, SLC1A2, SLC8A3, SMIM6, SOX10, SOX2, SOX8, ST8SIA2, STMN4, STOX1, TAF10, TBX3, TBX6, TCF21, TERT, TEX11, THPO, TIE1, TNFRSF11A, TP63, TRIB1, TRPC6, TRPM1, TSHR, TTPA, TUB, UBE4B, WDR72, WT1, XIRP2, ZFP36L1, ZFP36L2, ZFP42 | |
| GO:0010033 | Response to organic substance | 138 | 4.34 | <0.001 | ABCA2, ABCC2, ADCY1, AIM2, AKT2, ANGPT2, APLP1, AQP1, AQP4, ASNS, ATP6V0A4, AVPR2, BMP7, BMP8B, BRSK2, CACNB1, CAMK2A, CAMK2D, CCDC3, CCL23, CCR4, CD24, CD6, CD74, CFTR, CGN, CHRM1, CHRNA4, CNR1, CPB2, CRLF2, CSF2RA, CUX2, CXCL5, DBH, DDC, EGR2, ELANE, EPHA4, ESRRB, F2RL1, FABP4, FGF23, FOXO1, FOXP2, FZD10, GABRB1, GAL, GBP5, GHSR, GJB6, GPD1, GRIK5, HCN2, HCRTR1, HFE2, HID1, HIPK1, HNF4A, HPRT1, IBSP, IL2, IL22RA2, IL37, IRF4, ITIH4, KANK2, KHSRP, LATS2, LEP, LMO3, LPAL2, LRRC19, LRRC3, LTBP4, MAGI2, MAP2K7, MAPK4, MCF2, MEFV, MT1G, MTHFR, MTSS1L, NFATC4, NPPC, NR0B1, NR2F6, NRP2, NRXN1, NTRK3, P2RX2, P2RY1, PAK3, PAQR9, PCSK6, PELO, PGF, PID1, PIK3CG, PLCG2, POLB, POLR2A, PPARGC1A, PPARGC1B, PRKCB, PRLR, PSG1, RAPGEF1, RAPGEF3, RARRES2, RERG, RIPOR1, RNASE7, RNF31, RXRB, SIN3A, SLC11A1, SLC1A2, SLC8A3, SORBS1, SOST, SOX10, SOX2, SOX30, TAT, TCF21, TERT, THPO, TIE1, TNFRSF11A, TP63, TRIB1, TSHR, TUB, UBE4B, WT1, ZFP36L1, ZFP36L2 | |
| GO:0007399 | Nervous system development | 109 | 4.61 | <0.001 | ADCY1, AKT2, APLP1, AQP1, ARHGAP26, ASCL2, ATCAY, ATN1, AVPR2, BCAN, BMP7, BRSK1, BRSK2, CAMK2A, CAMK2D, CCK, CCR4, CHRM1, CNGB1, CNR1, CNTN4, CUX2, DMBX1, DRAXIN, EFNA2, EGR2, EMX1, EN2, EPHA4, EZH1, FEZF2, FOXG1, FOXP2, FZD10, GABRB1, GAL, GHSR, GPM6B, GPRC5B, HDAC10, HES4, HIPK1, HPRT1, IL2, KCNIP2, KLHL17, LEP, LHX2, LHX6, LHX8, LRRC7, LSAMP, LST1, MAB21L2, MAGI2, MARK4, MCF2, MEF2D, MINK1, MOBP, MYO7A, NDRG2, NEUROG2, NFATC4, NPAS1, NPPC, NR0B1, NR2F6, NRP2, NRXN1, NTRK3, OBSL1, OLFM1, P2RY1, PAK3, PCDH15, PCDH8, PCDHGC5, PPARGC1A, RAPGEF1, RAX, RFX4, RGS14, RIMS1, SCN3B, SCRT1, SDK2, SEMA4D, SEMA6B, SEZ6L, SH3TC2, SHANK3, SLC17A8, SLC1A2, SLC8A3, SOX10, SOX2, SOX8, ST8SIA2, STMN4, TBX3, TBX6, TERT, TP63, TRPC6, TRPM1, TSHR, UBE4B, ZFP36L1 | |
| GO:0007267 | Cell-cell signaling | 94 | 5.64 | 1.18× 10−8 | ADRB1, AMER3, ANPEP, AQP1, AXIN2, BRSK1, BRSK2, CACNB1, CADPS, CAMK2A, CCL23, CD24, CFTR, CHRM1, CHRNA4, CNR1, CNTN4, CUX2, CXCL5, DBH, DLGAP1, DRAXIN, EFNA2, EGR2, EPHA4, FGF23, FOXO1, FZD10, GAL, GHSR, GJA5, GPRC5B, GRID1, GRIK2, GRIK3, GRIK5, GRM2, GRM8, HCN2, HCRTR1, HMGA2, HNF4A, IL2, JPH3, KCNIP2, LATS2, LEP, LTBP4, MAGI2, MCHR1, MINK1, MYCBPAP, NDRG2, NETO1, NFATC4, NPBWR2, NPPC, NPTX2, NPY2R, NRXN1, P2RX2, P2RY1, PANX2, PCDH15, PCDH8, PCDHGC5, PGF, PKP2, PLCG2, RAPGEF1, RAPGEF3, RASL10B, RGS14, RIMS1, SCEL, SCN3B, SHANK3, SHISA9, SIRPG, SLC1A2, SLC5A7, SLC8A3, SORCS3, SOST, SOX10, SOX2, STXBP5L, SYNPO, TBX3, TERT, TNFRSF11A, TP63, TSHR, UNC13C | |
| Downregulated | GO:0045667 | Regulation of osteoblast differentiation | 5 | 4.42 | 0.001 | FGFR2, IL6ST, PIAS2, PRKD1, WNT4 |
| GO:0044774 | Mitotic DNA integrity checkpoint | 5 | 4.31 | 0.001 | CDK2, CNOT7, PLK3, TOP2A, TP73 | |
| GO:0021954 | Central nervous system neuron development | 4 | 5.41 | 0.001 | ADARB1, FGFR2, NFIB, SZT2 | |
| GO:0044819 | Mitotic G1/S transition checkpoint | 4 | 5.19 | 0.002 | CDK2, CNOT7, PLK3, TP73 | |
| GO:0031571 | Mitotic G1 DNA damage checkpoint | 4 | 5.19 | 0.002 | CDK2, CNOT7, PLK3, TP73 |
a
The top 5 terms were selected according to P-value.
b
Number of enriched genes for each term. GO, Gene Ontology; DEGs, differentially expressed genes; BP, biological process.
c
Represents the percentage of genes contained in each term to the upregulated or downregulated genes.