Table IV.

Topological parameters for the total, the upregulated and the downregulated PPI subnetworks.

PPI subnetwork	y=axb	R2	Correlation coefficient	Clustering coefficient	Network centralization	Network density
Total	y=256.19x−1.478	0.863	0.931	0.249	0.137	0.010
Upregulated	y=191.96x−1.462	0.901	0.939	0.256	0.153	0.012
Downregulated	y=18.646x−1.291	0.809	0.984	0.142	0.287	0.044

R² is a measure of the fit quality, with a range of 0–1 (a higher value indicates a better fit). The correlation between observations and the corresponding points on the fitted curve was determined. Clustering coefficient denotes an average of the clustering coefficients of all nodes in the network. Network centralization is a connectivity distribution index. Network density is the normalized value of the average number of neighbors. PPI, protein-protein interaction.