Table IV.
Radio/chemotherapy-associated toxicities of grade ≥3.
| Parameter | Total (n=70) (%) | SNR (n=27) (%) | DNR (n=30) (%) | NR (n=13) (%) |
|---|---|---|---|---|
| Acute toxicity | ||||
| Hematological toxicities (grade ≥3) | 35 (50.0) | 11 (40.7) | 20 (66.7) | 4 (30.8) |
| Leukopenia | 31 (44.3) | 8 (29.6) | 19 (63.3) | 4 (30.8) |
| Anemia | 7 (10.0) | 2 (7.4) | 5 (16.7) | 0 (0.0) |
| Thrombocytopenia | 10 (14.3) | 5 (18.5) | 5 (16.7) | 0 (0.0) |
| Non-hematological toxicities (grade ≥3) | 43 (61.4) | 17 (63.0) | 20 (66.7) | 6 (46.2) |
| Fatigue | 22 (31.4) | 7 (25.9) | 13 (43.3) | 2 (15.4) |
| Pneumonia | 6 (8.6) | 3 (16.7) | 1 (3.3) | 2 (15.4) |
| Esophagitis | 7 (10.0) | 2 (11.1) | 2 (6.7) | 3 (23.1) |
| Pain | 19 (27.1) | 7 (25.9) | 9 (30.0) | 3 (23.1) |
| Nausea | 6 (8.6) | 2 (7.4) | 4 (13.3) | 0 (0.0) |
| Vomiting | 8 (11.4) | 2 (7.4) | 6 (20.0) | 0 (0.0) |
| Diarrhea | 7 (10.0) | 5 (18.5) | 2 (6.7) | 0 (0.0) |
| GPT/GOT elevation | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Weight loss | 16 (22.9) | 5 (18.5) | 8 (26.7) | 3 (23.1) |
| Late toxicity | 6 (8.6) | 2 (7.4) | 2 (6.7) | 2 (1.5) |
| Pneumonitis | 5 (7.1) | 2 (7.4) | 2 (6.7) | 1 (7.7) |
| Heart disease | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Esophageal ulcer | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Esophageal stricture | 1 (1.4) | 0 (0.0) | 0 (0.0) | 1 (7.7) |
| Esophagitis | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
DNR, docetaxel, nedaplatin and radiotherapy; GOT, glutamic-oxaloacetic transaminase; GPT, glutamic-pyruvic transaminase; NR, nedaplatin and radiotherapy; SNR, S-1, nedaplatin and radiotherapy.