Figure 1.

(A) MR sequence for anatomical orientation. T2-weighted, coronally orientated MR image; the tumour in the right flank of the mouse is designated with the asterisk. (B) ROI placement for real-time dynamic gadofosveset-enhanced-MRI analysis. Contrast-enhanced, T1-weighted, axially orientated MR image. The tumour can be seen in the right flank of the mouse (roundish structure in the bottom left-hand corner of the image). A part of the tumour appeared necrotic, i.e., hypointense and non-enhancing in this sequence (asterisk). A ROI has been placed manually into the contrast-enhancing viable part of the tumour (red circle within the hyperintense area). MRI, magnetic resonance imaging; ROI, region of interest.