Table II.
Results of the Student's t-tests in the different AUC.b
| Scenario | Average AUC | Difference | |||||
|---|---|---|---|---|---|---|---|
| Normalized, min | AUC from time, min | AUC to time, min | tTF-NGR | Control | Absolute | Relative (%) | P-valuea |
| 8.3 | 8.3 | 30 | 2,085,311 | 2,203,500 | 118,190 | 5.7 | 0.0002 |
| 20 | 1,137,358 | 1,184,841 | 47,483 | 4.2 | 0.0001 | ||
| 15 | 664,323 | 683,336 | 19,013 | 2.9 | 0.0003 | ||
| 10 | 171,830 | 174,408 | 2,578 | 1.5 | 0.0024 | ||
| 9 | 9 | 30 | 2,028,616 | 2,095,892 | 67,276 | 3.3 | 0.0398 |
| 20 | 1,072,341 | 1,092,977 | 20,636 | 1.9 | 0.0997 | ||
| 15 | 595,217 | 599,203 | 3,986 | 0.7 | 0.2969 | ||
| 10 | 98,617 | 98,094 | −522 | −0.5 | 0.2732 | ||
| 10 | 10 | 30 | 1,947,814 | 2,016,251 | 68,437 | 3.5 | 0.0031 |
| 20 | 989,080 | 1,010,287 | 21,207 | 2.1 | 0.0054 | ||
| 15 | 510,565 | 515,004 | 4,439 | 0.9 | 0.0669 | ||
| Max intensity | Max intensity | 30 | 2,086,301 | 2,207,055 | 120,755 | 5.8 | 0.0009 |
a
Student's t-test.
b
The AUC for different time periods were analysed (threshold α=1%). The average AUC values of the intensity curves of the two groups (tTF-NGR vs. control) differ significantly in the majority of cases, except for the cases where only very short time intervals were compared, e.g., the interval between 9 and 10 min. AUC, area under the curve; tTF, truncated tissue factor.