Table I.

Correlation between DENR expression and clinicopathological features of patients with nine common cancer types.

			DENR expression
Type of cancer	Characteristic	Case (n)	High (n)	Low (n)	χ2 value	P-value
Hepatocellular carcinoma (primary data from GSE14520)	AFP (ng/ml−1)
	>300	100	69	31	25.407	<0.001
	≤300	118	41	77
	AJCC TNM stage
	I	93	41	52	6.005	0.049
	II	77	37	40
	III	39	32	17
	CLIP stage
	0	97	33	64	18.308	<0.001
	1	74	47	27
	2–5	48	30	18
Gastric cancer (primary data from GSE15459)	Lauren classification
	Diffuse	75	29	46	6.348	0.041
	Mixed	99	57	42
	Intestinal	18	10	8
	Subtype
	Invasive	51	28	23	55.099	<0.001
	Metabolic	40	2	28
	Unstable	70	54	16
	Proliferative	31	12	19
Lung cancer (primary data from GSE30219)	AJCC T stage
	I	166	68	98	11.694	0.008
	II	69	42	27
	III	31	20	11
	IV	21	12	9
	Lymph node metastasis
	Positive	93	63	30	16.878	<0.001
	Negative	208	83	115
Breast invasive carcinoma (primary data from TCGA)	Age/year
	≤65	759	357	402	8.461	0.004
	>65	319	181	138
	AJCC T stage
	T1	279	126	153	13.487	0.004
	T2	633	340	293
	T3	138	56	82
	T4	40	25	15
	AJCC N stage
	N0	515	253	262	9.324	0.025
	N1	361	173	188
	N2	120	75	45
	N3	77	34	43
Kidney chromophobe carcinoma (primary data from TCGA)	AJCC TNM stage
	I–III	60	27	33	6.600	0.010
	IV	6	6	0
Rectal adenocarcinoma (primary data from TCGA)	AJCC T stage
	T1	4	3	1	9.423	0.024
	T2	13	9	4
	T3	65	34	31
	T4	10	1	9
Pancreatic adenocarcinoma (primary data from TCGA)	Sex
	Male	98	60	38	10.989	<0.001
	Female	80	29	51
Head and neck carcinoma and vulvar carcinoma	Clinicopathological feature data for head and neck cancer and vulvar cancer in public databases were either non-significant or not available.

Data analysed by Chi-square test. DENR, density-regulated re-initiation and release factor; AFP, α-fetoprotein; AJCC, American Joint Committee on Cancer; CLIP, Cancer of the Liver Italian Program; TNM, tumour-node-metastases; T, tumour; N, lymph node; n, number of samples; TCGA, The Cancer Genome Atlas.