Skip to main content
. 2018 Oct 30;17(1):660–667. doi: 10.3892/ol.2018.9641

Figure 1.

Figure 1.

GRP78 and GRP94 expression is associated with p53 expression in human colon cancer cells. The expression levels of GRP78 and GRP94 (A) proteins and (B) mRNA in WT HCT116 cells increased following TSA treatment in a dose-dependent manner. Significant statistical differences were indicated for GRP78 and GRP94 at different concentration of TSA (1 vs. 0.2 µM; 0.2 vs. 0.04 µM; 0.2 vs. 0 µM), respectively; P<0.01). The expression levels of GRP78 and GRP94 (C) proteins and (D) mRNA in WT HCT116 cells increased following treatment with 1 µM TSA in a time-dependent manner. Significant statistical differences were indicated for GRP78 and GRP94 between different time points groups (0, 3, 8 and 24; 0 P<0.01). No association was identified between TSA treatment and the expression levels of GRP78 and GRP94 (E) proteins and (F) mRNA in HCT116 TP53(−/-) cells. TSA, trichostatin A; WT, wild type.