Table I.
Information and clinical data on the 24 included studies.
| Accession | First author | Publication year | Country | Experiment type | Platform | Sample type | Number of patients with HCC | Control patients | TP | FP | FN | TN | AUC | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PMID:21229610 | Xu et al (a) | 2011 | China | RT-qPCR | Serum | 101 | 89 | 85 | 24 | 16 | 65 | 0.870 | (33) | |
| PMID:22403344 | Liu et al (c) | 2012 | China | RT-qPCR | Serum | 57 | 59 | 51 | 17 | 6 | 42 | 0.865 | (34) | |
| PMID:26302751 | Amr et al (b) | 2015 | Egypt | RT-qPCR | Serum | 23 | 17 | 23 | 3 | 0 | 14 | 0.943 | (35) | |
| PMID:26669589 | Zhuang et al (a) | 2015 | China | RT-qPCR | Serum | 52 | 43 | 35 | 17 | 11 | 24 | 0.621 | (36) | |
| PMID:27113935 | El-Tawdi et al (a) | 2016 | Egypt | RT-qPCR | Serum | 78 | 42 | 73 | 2 | 5 | 40 | 0.957 | (14) | |
| PMID:27113935 | El-Tawdi et al (b) | 2016 | Egypt | RT-qPCR | Serum | 78 | 36 | 73 | 4 | 5 | 32 | 0.938 | (14) | |
| PMID:21749846 | Tomimaru et al (a) | 2012 | Japan | RT-qPCR | Plasma | 126 | 50 | 110 | 4 | 16 | 46 | 0.953 | (37) | |
| PMID:21749846 | Tomimaru et al (b) | 2012 | Japan | RT-qPCR | Plasma | 126 | 30 | 77 | 5 | 49 | 25 | 0.773 | (37) | |
| PMID:21283620 | Mizuguchi et al (b) | 2011 | Japan | RT-qPCR | Tissue | 22 | 22 | 17 | 6 | 5 | 16 | 0.780 | (38) | |
| PMID:28477010 | Guo et al (b) | 2017 | China | RT-qPCR | Serum | 175 | 64 | 135 | 9 | 40 | 55 | 0.789 | (24) | |
| PMID:28477010 | Guo et al (c) | 2017 | China | RT-qPCR | Serum | 175 | 278 | 144 | 45 | 31 | 233 | 0.849 | (24) | |
| CNKI | Qin et al (a) | 2013 | China | RT-qPCR | Plasma | 55 | 50 | 48 | 3 | 7 | 47 | 0.956 | (39) | |
| CNKI | Qin et al (b) | 2014 | China | RT-qPCR | Plasma | 55 | 60 | 34 | 10 | 21 | 50 | 0.771 | (39) | |
| GSE22058 | Burchard et al | 2010 | USA | Non-coding RNA profiling by array | GPL10457 | Tissue | 96 | 96 | 71 | 7 | 25 | 89 | 0.877 | (40) |
| GSE10694 | Li et al | 2008 | China | Non-coding RNA profiling by array | GPL6542 | Tissue | 78 | 88 | 61 | 62 | 17 | 26 | 0.506 | (41) |
| GSE41874 | Morita et al | 2013 | Japan | Non-coding RNA profiling by array | GPL7722 | Tissue | 6 | 4 | 3 | 0 | 3 | 4 | 0.625 | – |
| GSE21279 | Hou et al | 2010 | China | Non-coding RNA profiling by array | GPL9052 | Tissue | 4 | 11 | 3 | 1 | 1 | 10 | 0.841 | (42) |
| GSE57555 | Murakami et al | 2015 | Japan | Non-coding RNA profiling by array | GPL16699 | Tissue | 5 | 16 | 3 | 4 | 2 | 12 | 0.625 | (43) |
| GSE67882 | Ghosh et al | 2015 | India | Non-coding RNA profiling by array | GPL10850 | Tissue | 4 | 8 | 4 | 0 | 0 | 8 | 1.000 | – |
| GSE69580 | Hung et al | 2015 | China | Non-coding RNA profiling by array | GPL10850 | Tissue | 5 | 5 | 5 | 0 | 0 | 5 | 1.000 | – |
| GSE12717 | Su et al | 2008 | China | Non-coding RNA profiling by array | GPL7274 | Tissue | 10 | 6 | 10 | 2 | 0 | 4 | 0.800 | (44) |
| GSE54751 | Zhao et al | 2014 | USA | Expression profiling by RT-qPCR | GPL18262 | Tissue | 10 | 10 | 9 | 4 | 1 | 6 | 0.710 | (45) |
| GSE50013 | Shen et al | 2013 | USA | Expression profiling by RT-qPCR | GPL15497 | Plasma | 12 | 8 | 9 | 4 | 3 | 5 | 0.615 | (46) |
| TCGA | Tissue | 375 | 50 | 260 | 3 | 115 | 47 | 0.840 |
GO, Gene Ontology; HCC, hepatocellular carcinoma; AUC, area under the curve; TP, true positive; FP, false positive; FN, false negative; TN, true negative; RT-qPCR, reverse transcriptase-quantitative polymerase chain reaction, (a), healthy control group; (b), control group with chronic hepatitis B infection; (c), non-cancerous control group (healthy and chronic hepatitis B carriers); TCGA, The Cancer Genome Atlas.