Table II.

Summary estimates of diagnostic criteria and the 95% confidence intervals.

Analysis	Literature studies	Control group: Healthy	Control group: CHB	Integrated studies
Sensitivity (95% CI)	0.81 (0.79–0.83)	0.87 (0.83–0.90)	0.75 (0.71–0.79)	0.78 (0.76–0.80)
Specificity (95% CI)	0.82 (0.80–0.85)	0.82 (0.77–0.86)	0.84 (0.78–0.88)	0.79 (0.77–0.82)
Positive LR (95% CI)	4.56 (3.29–6.31)	6.22 (2.48–15.63)	4.36 (3.23–5.88)	4.46 (2.91–6.84)
Negative LR (95% CI)	0.21 (0.15–0.30)	0.17 (0.10–0.29)	0.27 (0.16–0.45)	0.26 (0.20–0.33)
DOR (95% CI)	24.56 (13.85–43.54)	39.09 (9.92–154.03)	18.66 (7.89–44.15)	20.17 (11.65–34.92)
AUC	0.904	0.926	0.904	0.887

CI, confidence interval; LR, likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve; CHB, chronic hepatitis B infection.