Table III.

Summary estimates of diagnostic criteria and the 95% confidence intervals of four subgroups.

Analysis	RT-qPCR subgroup	Non-coding RNA profiling by array subgroup	Tissue subgroup	Serum/plasma subgroup
Sensitivity (95% CI)	0.81 (0.79–0.83)	0.77 (0.71–0.83)	0.73 (0.69–0.76)	0.81 (0.7869–0.83)
Specificity (95% CI)	0.82 (0.79–0.84)	0.68 (0.61–0.74)	0.72 (0.67–0.77)	0.82 (0.79–0.85)
Positive LR (95% CI)	4.12 (3.02–5.61)	4.57 (1.30–16.06)	4.35 (1.66–11.39)	4.44 (3.16–6.25)
Negative LR (95% CI)	0.22 (0.15–0.30)	0.39 (0.24–0.64)	0.36 (0.28–0.47)	0.21 (0.15–0.30)
DOR (95% CI)	22.00 (12.73–38.01)	15.70 (3.32–74.29)	15.24 (5.00–46.45)	23.99 (13.27–43.37)
AUC	0.896	0.822	0.826	0.902

CI, confidence interval; LR, likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve; RT-qPCR, reverse transcriptase-quantitative polymerase chain reaction.