Table IV.
GO functional annotation of the target genes of miR-21-5p.
| GO ID | GO term | Category | Count | P-value | Correlation P-value |
|---|---|---|---|---|---|
| GO:0042221 | Response to chemical stimulus | BP | 20 | 2.08E-11 | 3.0689E-08 |
| GO:0043408 | Regulation of MAPKKK cascade | BP | 9 | 1.68E-10 | 1.173E-07 |
| GO:0010627 | Regulation of intracellular protein kinase cascade | BP | 11 | 2.39E-10 | 1.173E-07 |
| GO:0048518 | Positive regulation of biological process | BP | 21 | 4.33E-09 | 1.2905E-06 |
| GO:0050896 | Response to stimulus | BP | 26 | 4.92E-09 | 1.2905E-06 |
| GO:0010648 | Negative regulation of cell communication | BP | 10 | 5.26E-09 | 1.2905E-06 |
| GO:0042127 | Regulation of cell proliferation | BP | 14 | 6.66E-09 | 1.4006E-06 |
| GO:0048523 | Negative regulation of cellular process | BP | 19 | 1.09E-08 | 0.000002015 |
| GO:0009968 | Negative regulation of signal transduction | BP | 7 | 1.77E-08 | 0.000002835 |
| GO:0023057 | Negative regulation of signaling process | BP | 7 | 1.99E-08 | 0.000002835 |
| GO:0009986 | Cell surface | CC | 8 | 9.04E-07 | 0.00010939 |
| GO:0005896 | Interleukin-6 receptor complex | CC | 2 | 1.57E-05 | 0.00095048 |
| GO:0044459 | Plasma membrane part | CC | 14 | 8.66E-05 | 0.0034849 |
| GO:0043235 | Receptor complex | CC | 4 | 1.15E-04 | 0.0034849 |
| GO:0005886 | Plasma membrane | CC | 19 | 2.19E-04 | 0.0040511 |
| GO:0005615 | Extracellular space | CC | 8 | 2.57E-04 | 0.0040511 |
| GO:0005887 | Integral to plasma membrane | CC | 10 | 2.61E-04 | 0.0040511 |
| GO:0009897 | External side of plasma membrane | CC | 4 | 2.78E-04 | 0.0040511 |
| GO:0031226 | Intrinsic to plasma membrane | CC | 10 | 3.01E-04 | 0.0040511 |
| GO:0044421 | Extracellular region part | CC | 8 | 1.60E-03 | 0.019331 |
| GO:0019838 | Growth factor binding | MF | 6 | 2.10E-07 | 0.000056609 |
| GO:0034875 | Caffeine oxidase activity | MF | 2 | 3.53E-05 | 0.0031751 |
| GO:0033695 | Oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | MF | 2 | 3.53E-05 | 0.0031751 |
| GO:0016725 | Oxidoreductase activity, acting on CH or CH2 groups | MF | 2 | 2.62E-04 | 0.017694 |
| GO:0005496 | Steroid binding | MF | 3 | 5.66E-04 | 0.023457 |
| GO:0051117 | ATPase binding | MF | 2 | 6.07E-04 | 0.023457 |
| GO:0008083 | Growth factor activity | MF | 4 | 6.09E-04 | 0.023457 |
| GO:0060089 | Molecular transducer activity | MF | 13 | 1.17E-03 | 0.023457 |
| GO:0004871 | Signal transducer activity | MF | 13 | 1.17E-03 | 0.023457 |
| GO:0005125 | Cytokine activity | MF | 4 | 1.35E-03 | 0.023457 |
GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function.