Table II.

Risk of weight loss by cytokine genotype.

Polymorphism	WL5	WL5 (−)	Crude OR	aOR	WL10	WL10 (−)	Crude OR	aOR
IL-1B C-31T (rs1143627)
C/C	11	4	1	1	4	11	1	1
C/T	17	9	0.69	0.76	11	15	2.02	2.07
			(0.17–2.79)	(0.18–3.19)			(0.51–8.05)	(0.50–8.53)
T/T	4	6	0.24	0.20	4	6	1.83	1.73
			(0.04–1.33)	(0.03–1.19)			(0.33–10.10)	(0.31–9.78)
IL-1RN VNTR
L/L	31	17	1	1	18	30	1	1
L/2+2/2a	1	2	0.27	0.27	1	2	0.83	0.87
			(0.02–3.25)	(0.02–3.29)			(0.07–9.86)	(0.07–10.45)
IL-6 C-634G (rs1800796)
C/C	19	12	1	1	12	19	1	1
C/G	11	6	1.16	1.12	5	12	0.66	0.69
			(0.34–3.96)	(0.32–3.97)			(0.19–2.35)	(0.19–2.54)
G/G	2	1	1.26	1.11	2	1	3.17	3.32
			(0.10–15.49)	(0.08–14.89)			(0.26–38.84)	(0.25–44.45)
IL-8 T-251A (rs4073)
T/T	15	5	1	1	10	10	1	1
A/T	14	11	0.42	0.40	7	18	0.39	0.30
			(0.12–1.53)	(0.10–1.60)			(0.11–1.34)	(0.08–1.20)
A/A	3	3	0.33	0.33	2	4	0.50	0.46
			(0.05–2.21)	(0.05–2.26)			(0.07–3.38)	(0.06–3.29)
IL-10 T-819C (rs3021097)
T/T	11	10	1	1	5	16	1	1
C/T	19	8	2.16	2.48	12	15	2.56	3.24
			(0.66–7.10)	(0.71–8.69)			(0.73–9.01)	(0.84–12.43)
C/C	2	1	1.82	2.08	2	1	6.40	8.73
			(0.14–23.25)	(0.15–28.05)			(0.47–86.34)	(0.60–127.38) P for trend=0.046
C/T+C/C	21	9	2.12	2.44	14	16	2.80	3.55
			(0.67–6.76)	(0.72–8.30)			(0.82–9.62)	(0.94–13.35) P=0.061
IL-10 A-1082G (rs1800896)
A/A	30	15	1	1	17	28	1	1
A/G	2	4	0.25	0.22	2	4	0.82	0.75
			(0.04–1.52)	(0.04–1.43)			(0.14–4.99)	(0.12–4.65)

WL5 (10), indicates the number of subjects with weight loss more than 5% (or 10%); WL5 (10) (−), indicates those with no weight loss; OR, odds ratio (95% confidence interval in the parenthesis); aOR, adjusted odds ratio (adjusted for age and sex); IL, interleukin.

^aThose with L/2 and 2/2 genotypes were combined together because of the small number of the subjects in each stratum. Data for weight loss (body weights at two time-points; baseline and 6 months later) was available in 51 subjects.