Table IV.

Patient prognosis by cytokine genotypes.

Polymorphism	Comparison groups	Log-rank P	Model	Crude HR	aHR-1	aHR-2
IL-1B C-31T (rs1143627)	All 3 genotypes	0.916	Additive	1.03	0.89	0.74
				(0.53–2.00)	(0.39–2.03)	(0.33–1.65)
	vt. hetero+vt. homo vs. wt. homo	0.792	Dominant	1.16	1.02	0.93
				(0.39–3.44)	(0.29–3.54)	(0.27–3.21)
	vt. homo vs. others	0.889	Recessive	0.91	0.65	0.34
				(0.25–3.30)	(0.14–3.04)	(0.06–1.83)
IL-1RN VNTRa	All 3 genotypes	<0.0001	Additive	8.29	8.28	8.88
				(2.05–33.47)	(2.05–33.51)	(2.07–38.14)
	vt. hetero+vt. homo vs. wt. homo	0.010	Dominant	6.83	6.61	8.84
				(1.25–37.36)	(1.19–36.71)	(1.48–52.85)
	vt. homo vs. others	<0.0001	Recessive	–	–	–
IL-6 C-634G (rs1800796)	All 3 genotypes	0.0005	Additive	2.61	2.71	3.05
				(1.03–6.58)	(0.99–7.40)	(1.07–8.67)
	vt. hetero+vt. homo vs. wt. homo	0.206	Dominant	1.96	1.92	1.97
				(0.68–5.65)	(0.64–5.73)	(0.66–5.90)
	vt. homo vs. others	0.0001	Recessive	13.31	15.01	39.15
				(2.40–73.84)	(2.22–101.41)	(4.25–360.67)
IL-8 T-251A (rs4073)	All 3 genotypes	0.869	Additive	0.84	0.77	0.97
				(0.37–1.87)	(0.34–1.77)	(0.40–2.39)
	vt. hetero+vt. homo vs. wt. homo	0.798	Dominant	0.87	0.83	0.94
				(0.30–2.50)	(0.29–2.43)	(0.32–2.78)
	vt. homo vs. others	0.601	Recessive	0.58	0.43	1.07
				(0.08–4.49)	(0.05–3.77)	(0.11–10.23)
IL-10 T-819C (rs3021097)	All 3 genotypes	0.541	Additive	1.10	1.07	1.06
				(0.52–2.36)	(0.49–2.34)	(0.45–2.50)
	vt. hetero+vt. homo vs. wt. homo	0.478	Dominant	1.49	1.50	1.24
				(0.49–4.47)	(0.48–4.66)	(0.39–4.00)
	vt. homo vs. others	0.578	Recessive	0.57	0.50	0.74
				(0.07–4.34)	(0.06–3.96)	(0.09–5.87)
IL-10 A-1082G	A/G vs. A/A	0.198	–	2.66	2.98	6.48
(rs1800896)				(0.57–12.50)	(0.60–14.73)	(1.03–40.54)

HR, hazard ratio; aHR, adjusted hazard ratio (aHR-1, adjusted for sex and age; aHR-2, adjusted for age, sex and clinical stage [stage 4]).

^aFor IL-1RN VNTR, L/L, L/2, and 2/2 genotypes were defined as wt. homo, vt. hetero and vt. homo, respectively, where L allele includes 5- and 6-repeat allele.