Table I.
Current progress of patient-derived xenograft models.
| Author, year | Type of cancer | Processing method | Mouse strain | Implantation method | Implantation rate (%) | Stable take rate (%) | Time of tumor appearance | Stage of cancer | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|
| Cottu et al, 2012 | Breast | FTP | Nude | Fat pad | 36.1 (22/61) 4.2 (13/308) | <1 year | Primary (basal-like) Primary (non-basal-like) | (62) | |
| DeRose et al, 2011; Zhang et al, 2013 | NOD/SCID or SCID | Fat pad | 41 (77/186) | 16 (30/186) | 73–228 days | Primary | (63,64) | ||
| Kabos et al, 2012 | 41.6 (10/24) | <6 months | (65) | ||||||
| Petrillo et al, 2012 | 25 (5/20) | 1–3 months | (66) | ||||||
| Zhang et al, 2013 | NSG | Subcu | 31.3 (10/32) | 18.8 (6/32) | 30 weeks | (64) | |||
| Moro et al, 2012 | NSCLC | FTP | Nude | Subcu | 30–40 | Primary | (67) | ||
| NOD/SCID | RC | 90 | |||||||
| Nakajima et al, 2015 | Cells | NSG | Subcu | 42.1 (8/19) | 13–144 days | (68) | |||
| Julien et al, 2012 | Colorectal | FTP | Nude | Subcu | 54/85-20/26 | 59.4 days | Primary | (60) | |
| Dangles-Marie et al, 2007 | Cells | NOD/SCID | Subcu-injection | 84.4 (27/32) | Primary | (69) | |||
| Puig et al, 2013 | 100 (8/8) | Metastasis (liver) | (70) | ||||||
| Peng et al, 2013 | Head-neck | FTP | Nude | Subcu | 17 (5/30) | Primary | (71) | ||
| Priolo et al, 2010 | Prostate | FTP | Nude | RC | 39 (9/23) | <3 months | Primary | (72) | |
| NOD/SCID | 48 (11/23) | ||||||||
| Wetterauer et al, 2015 | NSG | Fat pad | 37 (10/27) | (73) | |||||
| Boone et al, 2015 | Ovarian | FTP | SCID | Subcu | 65–100 | Primary | (74) | ||
| Bankert et al, 2011 | Cells | NSG | Intra-injection | 85 (34/40) | 80–140 days | Primary (PSC) | (75) | ||
| 85 (17/20) | 116–177 days | Primary (Adenocarcinoma) | |||||||
| Han et al, 2012 | Stomach | FTP | Nude | Subcu | 94 (107/114) | Primary | (76) | ||
| Xue et al, 2012 | Pancreatic | NOD/SCID | RC | 90 | (77) | ||||
| Pavía-Jiménez et al, 2014 | Kidney | FTP | NOD/SCID | RC | 10–15 | Primary | (78) | ||
| Mohseni et al, 2014 | Nude | 67 | 13–63 days | Primary | (79) |
NSCLC, non small cell lung cancer; FTP, fresh tumor pieces; cells, tumor cell suspensions; subcu, subcutaneous implantation; fat pad, mammary fat pad; RC, implanted in renal capsule; subcu-injection, subcutaneous injection of cecum; intra-injection, intraperitoneal injection; PSC, papillary serous carcinoma; NOD, nonobese diabetic; SCID, severe combined immunodeficiency; NSG, NOD SCID γ.